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  6. Invitrogen™ DNA ligase IV Recombinant Rabbit Monoclonal Antibody (K01_1Q47)

Invitrogen™ DNA ligase IV Recombinant Rabbit Monoclonal Antibody (K01_1Q47)

Product Code. 30825421
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30825421 100 μL
30828187 50 μL
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Product Code. 30825421 Supplier Invitrogen™ Supplier No. MA563537

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Description

Rabbit Recombinant Monoclonal Antibody

DNA ligase IV Recombinant Monoclonal Antibody for Western Blot

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DNA ligase IV
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_1Q47
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene LIG4
Gene Accession No. P49917
Gene Alias 5830471N16Rik; DNA joinase; DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; DNA repair enzyme; Lig4; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase; tiny
Gene Symbols LIG4
Host Species Rabbit
Immunogen Recombinant protein of human DNA Ligase IV.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3981
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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