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DMX-5804, MedChemExpress

Product Code. 16480827
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Product Code. 16480827

Brand: Medchem Express HY111754

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Description

MedChemExpress DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.

Specifications

Chemical Name or Material DMX-5804
CAS 2306178-56-1
Color Off-White
Purity Grade Notes Research
Molecular Formula C21H19N3O3
Quantity 50 mg
Solubility Information DMSO : 125 mg/mL (345.89 mM; Need ultrasonic)
SMILES O=C1NC=NC2=C1C(C3=CC=C(OCCOC)C=C3)=CN2C4=CC=CC=C4
Molecular Weight (g/mol) 361.39
Formula Weight 361.39
Percent Purity 99.49%
Grade Research
Physical Form Powder
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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