Invitrogen™ DMP1 Polyclonal Antibody

Sheep Polyclonal Antibody

Brand:  Invitrogen™ PA547621

Product Code. 15558112

Description

In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human DMP-1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

Specifications

• Antigen: DMP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dmp1
• Gene Alias: AG1; ARHP; ARHR; AV020965; dentin matrix acidic phosphoprotein 1; dentin matrix protein 1; DENTMAT; Dmp; DMP 1; Dmp1; DMP-1; MGC130441; PP; serine rich acidic phosphoprotein
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13406
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O55188
• Gene Symbols: Dmp1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse DMP-1 Leu17-Tyr503.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG