DL-Thioctic acid, 98%, Thermo Scientific™

DL-Thioctic acid, CAS # 1077-28-7, is an antioxidant and coenzyme important for the activity of enzymes.

Brand:  Thermo Scientific Alfa Aesar L04711.06

Product Code. 11321687

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in in vivo studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages

Chemical Identifiers

• CAS: 1077-28-7
• Molecular Weight (g/mol): 206.32
• InChI Key: AGBQKNBQESQNJD-UHFFFAOYNA-N
• PubChem CID: 864
• IUPAC Name: 5-(1,2-dithiolan-3-yl)pentanoic acid

• Molecular Formula: C8H14O2S2
• MDL Number: MFCD00005474
• Synonym: dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acid
• ChEBI: CHEBI:16494
• SMILES: OC(=O)CCCCC1CCSS1

Specifications

• CAS: 1077-28-7
• Molecular Formula: C8H14O2S2
• Quantity: 5g
• Merck Index: 14,9326
• Solubility Information: Soluble in methanol,ethanol,diethyl ether and chloroform. Insoluble in water.
• SMILES: OC(=O)CCCCC1CCSS1
• Molecular Weight (g/mol): 206.32
• ChEBI: CHEBI:16494
• Percent Purity: 98%

• Boiling Point: 160°C to 165°C
• MDL Number: MFCD00005474
• Beilstein: 81853
• Synonym: dl-thioctic acid, thioctic acid, alpha-lipoic acid, 5-1,2-dithiolan-3-yl pentanoic acid, dl-alpha-lipoic acid, 1,2-dithiolane-3-pentanoic acid, 6,8-thioctic acid, thioctacid, 6-thioctic acid, alpha lipoic acid
• InChI Key: AGBQKNBQESQNJD-UHFFFAOYNA-N
• IUPAC Name: 5-(1,2-dithiolan-3-yl)pentanoic acid
• PubChem CID: 864
• Formula Weight: 206.33
• Chemical Name or Material: DL-Thioctic acid

Safety and Handling

Product Identifier

• DL-Thioctic acid

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : DL-Thioctic acid