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Thermo Scientific Chemicals DL-1,4-Dithiothreitol, 99%, for biochemistry

Catalog Number 10063023
1203.30 GBP valid until 2024-03-30
Use promo code "21648" to get your promotional price.


891.37 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.


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To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
3483-12-03
MFCD00004877
VHJLVAABSRFDPM-IMJSIDKUSA-N
dithiothreitol, dl-1,4-dithiothreitol, dl-dithiothreitol, 1,4-dithio-dl-threitol, d-1,4-dithiothreitol, d-dtt, 2s,3s-1,4-dimercaptobutane-2,3-diol, threo-1,4-dimercapto-2,3-butanediol, 1,4-dithiothreitol, dtt
446094
CHEBI:42170
(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
C(C(C(CS)O)O)S
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
3483-12-03
MFCD00004877
VHJLVAABSRFDPM-IMJSIDKUSA-N
dithiothreitol, dl-1,4-dithiothreitol, dl-dithiothreitol, 1,4-dithio-dl-threitol, d-1,4-dithiothreitol, d-dtt, 2s,3s-1,4-dimercaptobutane-2,3-diol, threo-1,4-dimercapto-2,3-butanediol, 1,4-dithiothreitol, dtt
446094
CHEBI:42170
(2S,3S)-1,4-bis(sulfanyl)butane-2,3-diol
C(C(C(CS)O)O)S

1,4-Dithiothreitol, CAS # 3483-12-3, is a reducing agent commonly used to reduce disulphide bonds in protein studies, such as western blot SDS-page electrophoresis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

  • 1,4-Dithiothreitol (DTT or Cleland's reagent) reduces disulfide bonds in proteins, leading to loss of native conformation
  • DTT is not stable in solution and should be prepared in small aliquots prior to use; the use of EDTA in the solution can increase the half-life of DTT
  • Typically used at a final concentration of 0.1M for protein stabilization; recommended to create a 1M stock

Applications

  • Protects thiol groups from oxidation and acts as a chemical chelator in solution; maintains proteins in the denatured state
  • Common applications include SDS-page electrophoresis and protein isolation
TRUSTED_SUSTAINABILITY
Absorbance (1M soln. in water), (1 M soln. in water) at 0nm, 0.035 max. at 500nm
Melting Point 39.0°C to 44.0°C
Color White
Boiling Point 125.0°C to 130.0°C (2.0 mmHg)
Flash Point >110°C
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (Iodimetry)
Packaging Glass bottle
Molecular Formula C4H10O2S2
Linear Formula HSCH2CH(OH)CH(OH)CH2SH
Quantity 100 g
Beilstein 01, III, 2360
Merck Index 15, 3419
Solubility Information Solubility in water: freely soluble. Other solubilities: freely soluble in ethanol,acetone,ether,,chloroform and ethyl acetate
Transmittance 99% min. (c=5, 660nm, water) 1cm cell
Molecular Weight (g/mol) 154.25
Formula Weight 154.25
Percent Purity 99%
Grade Biochemistry
Physical Form Powder
Chemical Name or Material DL-1, 4-Dithiothreitol
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Product Identifier
  • DL-1,4-Dithiothreitol
Signal Word
  • Warning
Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
  • H302-Harmful if swallowed.
Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.

RUO – Research Use Only

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