Invitrogen™ DISC1 Recombinant Rabbit Monoclonal Antibody (K01_1Q42)

Product Code.	Quantity
30828045	50 μL
30828608	100 μL

Product Code. 30828045 Supplier Invitrogen™ Supplier No. MA565230

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 60%, Pig - 60%, Cynomolgus monkey - 86%.

DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with multiple proteins of the centrosome and cytoskeletal system, and is involved in neuronal functions that are dependent upon proper cytoskeletal regulation, including neuronal migration, neurite architecture and intracellular transport. Regions of the brain which express DISC1 include the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, and loss of DISC1 function results in differences in structural organization.The DISC1 gene locus is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2, beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Specifications

• Antigen: DISC1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: K01_1Q42
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 50mM tris glycine with 0.05% BSA, 150mM NaCl, 40% glycerol and 0.01% sodium azide; pH 7.4
• Gene: DISC1
• Gene Accession No.: Q810H6, Q811T9, Q9NRI5
• Gene Alias: C1orf136; DISC1; disrupted in schizophrenia 1; disrupted in schizophrenia 1 homolog; Disrupted in schizophrenia 1 protein; KIAA0457; RP4-730B13.1; SCZD9
• Gene Symbols: DISC1
• Host Species: Rabbit
• Immunogen: Recombinant protein of human DISC1 (aa 1-100).
• Purification Method: Protein A/G
• Quantity: 50 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 244667, 27185, 307940
• Target Species: Human, Mouse, Rat
• Content And Storage: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG