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STEMCELL Technologies Dihydrolipoic Acid

Product Code. 17130252
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Quantity:
50 mg
Unit Size:
50mg
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Product Code. 17130252

Brand: STEMCELL Technologies 73622

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Description

Antioxidant; Reducing agent

  • Dihydrolipoic Acid (DHLA) is the reduced form of alpha-lipoic acid, and is a carboxylic acid containing two thiol groups (Moini et al.) It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species (ROS), including hydroxyl radicals, peroxynitrite, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01 - 0.5 mM (Moini et al.) Dihydrolipoic acid has also been shown to recycle ubiquinone to the antioxidant active divalently reduced form (Nohl & Gille)
  • Conversely, at concentrations higher than 50 - 100 μM, Dihydrolipoic acid directly increases the ROS content, along with a significant increase in cytoplasmic free calcium and nitric oxide (NO) levels, loss of mitochondrial membrane potential, activation of caspases-9 and -3, and cell death (Chan et al.; Houng et al.)

Specifications

CAS 462-20-4
Quantity 50 mg
Molecular Formula C8H16O2S2
Purity ≥95%
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