Diclofenac sodium salt

Product Code.	Quantity	unitSize
15484939	5 g	5g

Product Code. 15484939 Supplier Thermo Scientific Alfa Aesar Supplier No. J62609.06

Beskrivning

Standard NSAID and cyclooxygenase (COX) inhibitor | CAS: 15307-79-6 | C14H10Cl2NNaO2 | 318.129 g/mol

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Specifikationer

Kemiska identifierare

• CAS: 15307-79-6
• Molecular Formula: C14H10Cl2NNaO2
• Molecular Weight (g/mol): 318.129
• MDL Number: MFCD00082251
• InChI Key: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• Synonym: diclofenac sodium, sodium diclofenac, diclofenac sodium salt, voltaren, solaraze, anthraxiton, prophenatin, allvoran, batafil, delimon
• PubChem CID: 5018304
• ChEBI: CHEBI:4509
• IUPAC Name: sodium;2-[2-(2,6-dichloroanilino)phenyl]acetate
• SMILES: C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]

• Melting Point: 283°C to 285°C
• Color: White
• Quantity: 5 g
• UN Number: UN2811
• Merck Index: 14,3081
• Solubility Information: Soluble in water to 50mg/ml.
• Formula Weight: 318.14
• Physical Form: Powder
• Chemical Name or Material: Diclofenac sodium salt

Säkerhet och hantering

Produktbeteckning

• Diclofenac sodium salt

Signalord

• Danger

Riskkategorier

• Acute toxicity Category 3

Faroangivelser

• H301-Toxic if swallowed.

Skyddsangivelse

• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /

Kompletterande information

• MIXTURE LIST-Contain: Diclofenac sodium salt

SDS

RUO – Research Use Only