Dexamethasone, 98%, Thermo Scientific™

Product Code	Brand	Quantity
11428217	Thermo Scientific Alfa Aesar A17590.14	25g

Description

Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.

Solubility
Soluble in ethanol and dimethyl sulfoxide. Insoluble in water.

Notes
Store in cool place. Light sensitive. Incompatible with strong oxidizing agents.

Chemical Identifiers

• CAS: 50-02-2
• Molecular Weight (g/mol): 392.47
• InChI Key: UREBDLICKHMUKA-CXSFZGCWSA-N
• PubChem CID: 5743
• IUPAC Name: (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one

• Molecular Formula: C22H29FO5
• MDL Number: MFCD00064136
• Synonym: dexamethasone, decadron, dexamethazone, maxidex, decaspray, desametasone, hexadecadrol, dexacort, dexasone, hexadrol
• ChEBI: CHEBI:41879
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

Specifications

• CAS: 50-02-2
• Molecular Formula: C22H29FO5
• Beilstein: 2066651
• Merck Index: 142943
• Solubility Information: Soluble in ethanol and dimethyl sulfoxide. Insoluble in water.
• Optical Rotation: +75° (c=1 in Doxane)
• IUPAC Name: (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
• PubChem CID: 5743
• Formula Weight: 392.47
• Chemical Name or Material: Dexamethasone

• Assay Percent Range: 0.98
• MDL Number: MFCD00064136
• Sensitivity: Light sensitive
• Synonym: dexamethasone, decadron, dexamethazone, maxidex, decaspray, desametasone, hexadecadrol, dexacort, dexasone, hexadrol
• InChI Key: UREBDLICKHMUKA-CXSFZGCWSA-N
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• Molecular Weight (g/mol): 392.47
• ChEBI: CHEBI:41879
• Percent Purity: 98%

Safety and Handling

Suspected of causing cancer

Carcinogenicity (category 2)

missing translation for 'einecsNumber' : 200-003-9

missing translation for 'rtecsNumber' : TU3980000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

RUO – Research Use Only