Invitrogen™ Desmin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA585187

Product Code. 16312135

Description

Keep as concentrated solution. Predicted reactivity: Mouse (98%), Rat (99%), Dog (99%), Pig (99%), Rabbit (99%), Rhesus Monkey (99%), Bovine (99%). Positive Control: RD, mouse muscle. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Specifications

• Antigen: Desmin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DES
• Gene Alias: CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13346, 1674, 395906, 396725, 64362
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.42 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P02540, P02542, P17661, P31001, P48675
• Gene Symbols: DES
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Desmin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Pig, Chicken
• Product Type: Antibody
• Isotype: IgG