Invitrogen™ DDX50 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA597136

Product Code. 16529971

Description

Immunogen sequence: MPGKLLWGDI MELEAPLEES ESQKKERQKS DRRKSRHHYD SDEKSETREN GVTDDLDAPK AKKSKMKEKL NGDTEEGFNR LSDEFSKSHK SRRKDLPNGD IDEYEKKSKR VSSLDTSTHK SSDNKLEETL TREQK; Positive Samples: A-431, Jurkat, HepG2; Cellular Location: Nucleus, nucleolus.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX50 is a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. DDX50 and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. DDX50 gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined.

Specifications

• Antigen: DDX50
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DDX50
• Gene Alias: 4933429B04Rik; 8430408E17Rik; ATP-dependent RNA helicase DDX50; ATP-dependent RNA helicase DDX50-like protein; Ddx50; DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD box protein 50; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50; DEAD-box helicase 50; DExD-box helicase 50; GU2; GUB; Gubeta; gu-beta; malignant cell derived RNA helicase; mcdrh; Nucleolar protein Gu2; RH-II; RH-II/GuB; RH-II/Gubeta; RNA helicase II/Gu beta; Unknown (protein for IMAGE:8120580)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361848, 79009, 94213
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.45 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q99MJ9, Q9BQ39
• Gene Symbols: DDX50
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-135 of human DDX50 (NP_0769501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG