Invitrogen™ DDX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583227

Product Code. 16360185

Description

Immunogen sequence: LGKSHIRTDD VHAKDNTRPG ANSPEMWSEA IKILKGEYAV RAIKEHKMDQ AIIFCRTKID CDNLEQYFIQ QGGGPDKKGH QFSCVCLHGD Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.

DDX1 (ATP-dependent RNA helicase DDX1) acts as an ATP-dependent RNA helicase. It is able to unwind both RNA-RNA and RNA-DNA duplexes. DDX1 possesses 5' single-stranded RNA overhand nuclease activity and ATPase activity on various RNA, but not DNA polynucleotides. DDX1, together with RELA, acts as a coactivator to enhance NF-kappa-b-mediated transcriptional activation. It also acts as a positive transcriptional regulator of cyclin CCND2 expression. It binds to the cyclin CCND2 promoter region. DDX1 is a component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double stranded RNA and plays a role in activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1.

Specifications

• Antigen: DDX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DDX1
• Gene Alias: AA409185; ATP-dependent RNA helicase DDX1; DBP-RB; Ddx1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box polypeptide 1; DEAD box protein 1; DEAD box protein retinoblastoma; DEAD box-1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1; DEAD/H-box helicase 1; UKVH5d
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 104721, 1653, 84474
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q641Y8, Q91VR5, Q92499
• Gene Symbols: DDX1
• Immunogen: Recombinant protein corresponding to Human DDX1. Recombinant protein control fragment (Product #RP-95988).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG