Invitrogen™ DCUN1D1 Polyclonal Antibody

Goat Polyclonal Antibody

Marca:  Invitrogen™ PA519284

Codice prodotto. 11337263

Descrizione

This antibody is predicted to react with bovine and mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt].

Specifica

• Antigen: DCUN1D1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCUN1D1
• Gene Alias: DCN1; DCN1, defective in cullin neddylation 1, domain containing 1; DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Dcun1d1; DCUN1L1; defective in cullin neddylation 1 domain containing 1; defective in cullin neddylation protein 1-like protein 1; pTes3; Rp42; RP42 homolog; SCCRO; SCRO; squamous cell carcinoma related oncogene; squamous cell carcinoma-related oncogene; Tes3; testis derived transcript 3; testis-specific protein 3
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 54165
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96GG9
• Gene Symbols: DCUN1D1
• Immunogen: Synthetic peptide sequence (RPQIAGTKSTT) corresponding to the C-terminus amino acids of DCUN1D1 (aa 248-259).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG