Invitrogen™ DCT Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552736

Product Code. 15700691

Description

Immunogen sequence: WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS VYDF Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 46%.

The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.

Specifications

• Antigen: DCT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCT
• Gene Alias: Dct; DOPAchrome conversion factor; dopachrome delta isomerase; dopachrome delta-isomerase; DOPAchrome isomerase; DOPAchrome oxidoreductase; dopachrome tautomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; hypothetical protein LOC664745; L-dopachrome Delta-isomerase; L-dopachrome isomerase; L-dopachrome tautomerase; melanogenic enzyme; tyrosinase-related protein 2; trp2; RGD1564975; slaty; SLATY locus protein; slt; trp2; TRP-2; tyrosinase related protein 2; tyrosinase related protein-2; tyrosinase-related protein 2; tyrosinase-related protein-2; tyrosine-related protein 2; Tyrp2; Tyrp-2; zgc:109860
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1638
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P40126
• Gene Symbols: DCT
• Immunogen: Recombinant protein corresponding to Human DCT. Recombinant protein control fragment (Product #RP-89997).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG