Invitrogen™ DcR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA586474

Product Code. 16383355

Description

Purity is > 95% by SDS-PAGE.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Specifications

• Antigen: DcR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF6B
• Gene Alias: DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; decoy receptor for Fas ligand; DJ583P15.1.1; hCG_2044836; M68; M68E; OTTHUMP00000031583; TNF receptor superfamily member 6b; TNFRSF6B; TR6; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy; UNQ186/PRO212
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8771
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95407
• Gene Symbols: TNFRSF6B
• Immunogen: Synthetic peptide, corresponding to amino acids 251-300 of Human DcR3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG