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Invitrogen™ DcR3 Polyclonal Antibody

Product Code. 12818142
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Quantity:
100 μg
Unit Size:
100µg
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12818142 100 μg 100µg
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Product Code. 12818142 Supplier Invitrogen™ Supplier No. PA519924

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~33kDa. A suggested positive control is human heart tissue lysate. PA5-19924 can be used with blocking peptide PEP-0049.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DcR3
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TNFRSF6B
Gene Accession No. O95407
Gene Alias DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; decoy receptor for Fas ligand; DJ583P15.1.1; hCG_2044836; M68; M68E; OTTHUMP00000031583; TNF receptor superfamily member 6b; TNFRSF6B; TR6; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy; UNQ186/PRO212
Gene Symbols TNFRSF6B
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the amino terminus of human DcR3 precursor.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8771
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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