DCLK1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA595770

Product Code. 16558611

Description

Immunogen sequence: VDVDQRFSAV QVLEHPWVND DGLPENEHQL SVAGKIKKHF NTGPKPNSTA AGVSVIALDH GFTIKRSGSL DYYQQPGMYW IRPPLLIRRG RFSDEDATRM; Positive Samples: HepG2, A-549, 22Rv1, Mouse heart

DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.

Specifications

• Antigen: DCLK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCLK1
• Gene Alias: 1700113D08Rik, 2810480F11Rik, AI836758, Ania4, Calcium/calmodulin-dependent protein kinase type I-like CPG16, CL1, CLICK1, Click-I, CLICK-I beta, Cpg16, Dcamkl1, DCDC3A, Dcl, Dclk, Dclk1, double cortin and calcium/calmodulin-dependent protein kinase-like 1, doublecortin and calcium/calmodulin-dependent protein kinase-like 1, doublecortin domain-containing protein 3A, doublecortin like kinase 1, doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1, KIAA0369, mKIAA0369, RP11-113P14.1, Serine/threonine-protein kinase DCLK1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13175, 9201
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 2.29 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: O15075, Q9JLM8
• Gene Symbols: DCLK1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 630-729 of human DCAMKL1/DCAMKL1/DCLK1 (NP_0047251)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG