missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ DBZ

Tocris Bioscience™ DBZ
GREENER_CHOICE

Product Code. 18710688
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18710688 10 mg 10mg
18724957 50 mg 50mg
2 options
This item is not returnable. View return policy

Product Code. 18710688

Brand: Tocris Bioscience™ 4489/10

Please to purchase this item. Need a web account? Register with us today!

227.00 GBP valid until 2026-03-31
BEST PRICE on Promo! Use promo code "27931" to get your promotional price.
This item is not returnable. View return policy

Description

γ-secretase inhibitor; inhibits Notch pathway

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material DBZ
CAS 209984-56-5
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C26H23F2N3O3
Formula Weight 463.48
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.