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dBET57, MedChemExpress

Product Code. 16461367
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Product Code. 16461367 Supplier Medchem Express Supplier No. HY123844
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Estimated Shipment: 16-10-2026
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Description

MedChemExpress dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4Cereblon E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2.

dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4Cereblon E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2.

Specifications

Chemical Name or Material dBET57
CAS 1883863-52-2
Color Yellow
Purity Grade Notes Research
Molecular Formula C34H31ClN8O5S
Quantity 50 mg
Solubility Information DMSO : 250 mg/mL (357.56 mM; Need ultrasonic)
SMILES O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
Molecular Weight (g/mol) 699.18
Formula Weight 699.18
Percent Purity 99.66%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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