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DAPT, MedChemExpress

Product Code. p-200098977
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Quantity:
5 mg
10 mg
50 mg
Unit Size:
10mg
50mg
5mg
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Product Code. 16478207

Brand: Medchem Express HY13027

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Description

MedChemExpress DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively.

DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.

Specifications

Chemical Name or Material DAPT
CAS 208255-80-5
Color White
Purity Grade Notes Research
Molecular Formula C23H26F2N2O4
Quantity 5 mg
Synonym GSI-IX
Solubility Information DMSO : 62.5 mg/mL (144.52 mM; Need ultrasonic) ∣Ethanol : 10 mg/mL (23.12 mM; Need ultrasonic)
SMILES FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Molecular Weight (g/mol) 432.46
Formula Weight 432.46
Percent Purity 99.62%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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