DAPT, MedChemExpress

Product Code.	Quantity	unitSize
16478207	5 mg	5mg
16435498	10 mg	10mg
16491667	50 mg	50mg

Product Code. 16478207

Brand: Medchem Express HY13027

Description

MedChemExpress DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively.

DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.

Specifications

• Chemical Name or Material: DAPT
• CAS: 208255-80-5
• Color: White
• Purity Grade Notes: Research
• Molecular Formula: C₂₃H₂₆F₂N₂O₄
• Quantity: 5 mg
• Synonym: GSI-IX
• Solubility Information: DMSO : 62.5 mg/mL (144.52 mM; Need ultrasonic) ∣Ethanol : 10 mg/mL (23.12 mM; Need ultrasonic)
• SMILES: FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
• Molecular Weight (g/mol): 432.46
• Formula Weight: 432.46
• Percent Purity: 99.62%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-programmed cell death

Research purposes only