Invitrogen™ DAND5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583661

Product Code. 16360615

Description

Immunogen sequence: GMCKAVPFVQ VFSRPGCSAI RLRNHLCFGH CSSLYIPGSD PTPLVLCNSC MPARKRWAPV VLWCLTGSSA SRRRVKISTM LIEGCHCSPK A Highest antigen sequence indentity to the following orthologs: Mouse - 65%, Rat - 65%.

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Specifications

• Antigen: DAND5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAND5
• Gene Alias: CER2; CER2CRL2; cerberus 2; Cerberus like-2; cerberus-like 2; cerberus-like protein 2; Cerl2; Cerl-2; Cerr2; CKTSF1B3; CKTSF1B3MGC126849; coco; CRL2; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain BMP antagonist family member 5; DAN domain family member 5; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; Dand5; DANTE; Dte; FLJ38607; GREM3; GREM3cerberus 2; gremlin-3; MGC126849; SP1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 199699
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N907
• Gene Symbols: DAND5
• Immunogen: Recombinant protein corresponding to Human DAND5. Recombinant protein control fragment (Product #RP-99178).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG