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Invitrogen™ DACT3 Polyclonal Antibody

Product Code. 12818782
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Quantity:
100 μg
Unit Size:
100µg
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12818782 100 μg 100µg
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Product Code. 12818782 Supplier Invitrogen™ Supplier No. PA520630

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20630 can be used with blocking peptide PEP-0750.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACT3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene DACT3
Gene Accession No. Q0PHV7, Q96B18
Gene Alias Antagonist of beta-catenin Dapper homolog 3; arginine-rich region 1 protein; dact 3; Dact3; Dapper antagonist of catenin 3; dapper homolog 3; dapper homolog 3, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 3; DAPPER3; dishevelled binding antagonist of beta catenin 3; dishevelled-binding antagonist of beta-catenin 3; EG666671; naa-3; RGD1563892; RRR1
Gene Symbols DACT3
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the amino terminus of human Dact3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147906, 499088, 629378
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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