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Invitrogen™ DACT2 Polyclonal Antibody

Product Code. 12808782
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Quantity:
100 μg
Unit Size:
100µg
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12808782 100 μg 100µg
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Product Code. 12808782 Supplier Invitrogen™ Supplier No. PA520629

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20629 can be used with blocking peptide PEP-0749.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACT2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene DACT2
Gene Accession No. Q5SW24, Q7TN08
Gene Alias 2900084M21Rik; A630024E20; bA503C24.7; C6orf116; Dact2; Dapper antagonist of catenin 2; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin; dapper homolog 2, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 2; DAPPER2; dishevelled binding antagonist of beta catenin 2; dishevelled-binding antagonist of beta-catenin 2; Dpr2; Frd2; mDpr2; PP13671; RP11-503C24.7
Gene Symbols DACT2
Host Species Rabbit
Immunogen a 12 amino acid peptide from near the amino terminus of human DACT2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 168002, 240025, 308212
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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