DACH1 Rabbit anti-Human, CoraLite 594, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech CL594-10914-100UL

Product Code. 17214776

Description

DACH1, a homologue of the Drosophila dachshund gene, is a key regulator of cell fate determination during eye, leg, and brain development in the fly. Through interacting with NCoR and Smad4, DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1, suggesting a possible role in tumor suppression. Additionally, DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells, and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human DACH1.

Specifications

• Antigen: DACH1
• Classification: Polyclonal
• Host Species: Rabbit
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG

• Applications: Immunofluorescence
• Conjugate: CoraLite 594
• Quantity: 100 μL
• Gene ID (Entrez): 1602
• Form: Liquid