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  5. STEMCELL Technologies D4476

STEMCELL Technologies D4476

Product Code. 17100312
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Quantity:
5 mg
10 mg
Unit Size:
10mg
5mg
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Product Code. 17100312

Brand: STEMCELL Technologies 74012

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This item is not returnable. View return policy

Description

Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK

  • D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.) It inhibits CK1 and CK1δ from S
  • pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.) It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.)
  • Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.)
  • Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.)
  • Induces apoptosis of multiple myeloma cell lines (Hu et al.)
  • Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.)

Specifications

CAS 301836-43-1
Synonym Casein Kinase I Inhibitor
Quantity 5 mg
Molecular Formula C23H18N4O3
Purity ≥98%
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