Cytarabine, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity	Packaging
15244774	Thermo Scientific Acros 449561000	100 mg	Glass bottle
15224774	Thermo Scientific Acros 449560010	1 g	Glass bottle
15234774	Thermo Scientific Acros 449560050	5 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Cytarabine is a nucleoside analog that acts as an antileukemic agent

Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha

Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells

Applications

Has been used to study chemotherapeutic regimens in laboratory studies of leukemia

Useful for laboratory studies of cytarabine resistance mechanisms

At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members

It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks

Chemical Identifiers

• CAS: 147-94-4
• Molecular Weight (g/mol): 243.22
• Synonym: cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
• ChEBI: CHEBI:28680
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

• Molecular Formula: C₉H₁₃N₃O₅
• InChI Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• PubChem CID: 6253
• IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Specifications

• CAS: 147-94-4
• Assay Percent Range: 97.5% min. (HPLC)
• Merck Index: 152781
• Solubility Information: Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
• Molecular Weight (g/mol): 243.22
• ChEBI: CHEBI:28680
• Percent Purity: 98%

• Melting Point: 220.0°C
• Molecular Formula: C₉H₁₃N₃O₅
• Synonym: cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
• InChI Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• PubChem CID: 6253
• Formula Weight: 243.22
• Chemical Name or Material: Cytarabine

Safety and Handling

Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction

Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)

missing translation for 'einecsNumber' : 205-705-9

Product Identifier

• Cytosine beta-D-arabinofuranoside

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 2
• Respiratory sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H361d-Suspected of damaging the unborn child.
• H319-Causes serious eye irritation.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

RUO – Research Use Only