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Cytokeratin 19, clone: BA17, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9898-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288217

  • £55.52 / 25Āµg


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Description

Description

Description: This BA17 monoclonal antibody reacts with human cytokeratin 19 (CK19), a 44-kDa type I (acidic) intermediate filament protein that lacks the non-alpha-helical tail domain present in other keratins. Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues. Cytokeratin 19 is expressed in a wide variety of simple and stratified epithelial tissue. Moreover, cytokeratin 19 expression can be induced by vitamin A, SV40 transformation, and cancer. A soluble form of cytokeratin 19 generated by caspase 3 cleavage has also been found to be secreted by cancer cells, thus possibly indicating tumor metastasis. Cytokeratin 19 often exists as a heterodimer with cytokeratin 7, a type II keratin.Applications Reported: This BA17 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections and immunocytochemistry.Applications Tested: This BA17 antibody has been tested by immunocytochemistry of fixed and permeabilized MCF-7 cells. This can be used at less than or equal to 10 ug/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Cytokeratin 19
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P08727
CK-19, Keratin-19, K19
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ImmunocytochemistryĆ¾Immunohistochemistry
BA17
Unconjugated
KRT19
Purified
KRT19
IgG1, kappa
25μg
Store at 2-8°C.
Primary
3880
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