Invitrogen™ CYP2R1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587927

Product Code. 16556281

Description

Immunogen sequence: VVYDFLSRLI EKASVNRKPQ LPQHFVDAYL DEMDQGKNDP SSTFSKENLI FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMGPNGKPS WDDKCKMPYT EAVLHEVLRF CNIVPLGIFH ATSEDAVVRG YSIPKGTTVI TNLYSVHFDE KYWRDPEVFH PERFLDSSGY FAKKEALVPF SLGRRHCLGE HLARMEMFLF FTALLQRFHL HFPHELVPDL KPRLGMTLQP QPYLICAERR; Positive Samples: Mouse testis, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.

CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.

Specifications

• Antigen: CYP2R1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cyp2r1
• Gene Alias: Cyp2r1; Cytochrome P450 2R1; cytochrome P450 family 2 subfamily R member 1; cytochrome P450, 2r1; cytochrome P450, family 2, R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 244209, 361631
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q6VVW9
• Gene Symbols: Cyp2r1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 252-501 of human CYP2R1 (NP_0787902).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG