Invitrogen™ CYP2A6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527890

Product Code. 13432007

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.

Specifications

• Antigen: CYP2A6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYP2A6
• Gene Alias: 1,4-cineole 2-exo-monooxygenase; Coumarin 7-hydroxylase; CPA6; CYP; CYP2A; CYP2A3; CYP2A6; CYPIIA6; cytochrome P450 2A6; cytochrome P450 family 2 subfamily A member 6; cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450; P450 IIA3; P450(I); P450C2A; P450PB; xenobiotic monooxygenase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1548
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P11509
• Gene Symbols: CYP2A6
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Cytochrome P450 2A6. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG