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Thermo Scientific™ CYP1A2 BACULOSOMES™ Plus Reagent, rHuman

Product Code. 10738273
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Quantity:
0.5 nmol
Unit Size:
Each
This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Product Code. 10738273

Brand: Thermo Scientific™ P2792

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Beskrivning

Cytochrome P450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells infected with recombinant baculovirus containing a human CYP450 isozyme, as well as human cytochrome P450 reductase.

Cytochrome P450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells infected with recombinant baculovirus containing a human CYP450 isozyme, as well as human cytochrome P450 reductase.

  • Single human P450 isozyme for detailed drug metabolism studies
  • High specific activity increases dynamic range and sensitivity
  • No background metabolism for clear results

Single Overexpressed Human CYP450 Isozyme

CYP450 BACULOSOMES™ Plus Reagents offer a distinct advantage over Human Liver Microsomes (HLMs) in that only one CYP450 isozyme is expressed, thereby preventing metabolism by other CYP450s or other classes of drug metabolizing enzymes.

High Activity Results in Increased Sensitivity

Compound rankings based on metabolism and inhibition profiles observed with CYP450 BACULOSOMES™ Plus Reagents are very similar to those seen with HLMs for most compounds tested. However, CYP450 BACULOSOMES™ Plus Reagents activity and metabolic rates with most substrates is significantly higher than those seen with HLMs. This results in a broad dynamic range and high sensitivity in assays utilizing CYP450 BACULOSOMES™ Plus Reagents. The high level of activity and reproducibility of the enzyme component observed in the reaction with most probe substrates makes CYP450 BACULOSOMES™ Plus Reagents well suited to high-throughput screening formats.

High Signal to Noise Ratio

No background metabolism by endogenous insect CYP450s has been detected with any of the Vivid™ probe substrates tested so far.

Applications

  • Isozyme identification
  • DMPK analysis
  • Isozyme-specific metabolism
  • Inhibition screening
TRUSTED_SUSTAINABILITY

Specifikationer

Product Line BACULOSOMES
For Use With (Application) Cell viability, proliferation and function, hepatocytes and hepatic models, pharma and biopharma, protein assays and analysis, target-based ADME/Tox assays, isozyme identification, dmpk analysis, isozyme-specific metabolism, and inhibition screening
Content And Storage Store at -80°C., -80°C
Product Type Bacterial Microsome, CYP1A2 BACULOSOMES™ Plus Reagent
Quantity 0.5 nmol
Shipping Condition Dry Ice
Research Category Toxicology & Drug Metabolism
Species Human

For Research Use Only. Not for use in diagnostic procedures.

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