CYFIP1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16815454	Proteintech 16011-1-AP-20UL	20 μL
16805454	Proteintech 16011-1-AP-150UL	150 μL

Description

This antibody can recognize both CYFIP1 and CYFIP2.

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Specifications

• Antigen: CYFIP1/2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q5SQX6, Q7L576, Q7TMB8, Q96F07
• Gene ID (Entrez): 20430, 23191, 26999, 76884
• Immunogen: CYFIP1/2 Fusion Protein Ag8749
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CYFIP1

• Concentration: 0.19 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CYFIP2, KIAA1168, p53 inducible protein 121, PIR121
• Gene Symbols: Cyfip1, Cyfip2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody