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Cyclopamine, 99%

Product Code. 15484109
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Product Code. 15484109 Supplier Thermo Scientific Alfa Aesar Supplier No. J61528.MB
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Description

CAS: 4449-51-8 | C27H41NO2 | 411.63 g/mol

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Solubility
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 4449-51-8
Molecular Formula C27H41NO2
Molecular Weight (g/mol) 411.63
MDL Number MFCD01735266
InChI Key QASFUMOKHFSJGL-LAFRSMQTSA-N
Synonym cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
PubChem CID 122130428
SMILES C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C

Specifications

Melting Point 234°C to 237°C
Color White
Quantity 25 mg
Solubility Information Soluble in ethanol (5mg/ml warm),DMSO (4mg/ml),DMF (10mg/ml),methylene chloride,chloroform,methanol (7mg/ml),and benzene.
IUPAC Name (3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Formula Weight 411.62
Percent Purity ≥99%
Physical Form Powder
Chemical Name or Material Cyclopamine

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