missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. STEMCELL Technologies Cyclopamine

STEMCELL Technologies Cyclopamine

Product Code. 17120022
Encompass_Preferred
Change view
Click to view available options
Quantity:
1 mg
5 mg
Unit Size:
1mg
5mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
17120022 1 mg 1mg
17130022 5 mg 5mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 17120022 Supplier STEMCELL Technologies Supplier No. 72072

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Hedgehog pathway inhibitor; Inhibits Smoothened (SMO)

  • Cyclopamine is a steroid alkaloid that inhibits the Hedgehog pathway at the point of the pathway activator Smoothened
  • Cyclopamine binds to the heptahelical bundle of Smoothened, a G protein-coupled receptor, and prevents it from signaling further downstream (Chen et al.)
  • Reduces proliferation of rat neural progenitor cells and mouse neurospheres (Lai et al.; Palma and Ruiz i Altaba)
  • Reduces proliferation of mouse mammospheres (Liu et al.)
  • Promotes differentiation of pancreatic cells from human embryonic stem cells (D'Amour et al.)
  • Inhibits the growth of human and mouse medulloblastoma cells, and human glioblastoma cells (Bar et al.), Berman et al.)

Specifications

CAS 4449-51-8
Synonym 11-Deoxojervine; Jervine
Quantity 1 mg
Molecular Formula C27H41NO2
Purity ≥95%
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.