Invitrogen™ Cyclin H Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5105282

Product Code. 16671725

Description

Antibody detects endogenous levels of total Cyclin H.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.

Specifications

• Antigen: Cyclin H
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNH
• Gene Alias: 6330408H09Rik; AI661354; AV102684; AW538719; CAK; CAK complex subunit; Ccnh; CDK-activating kinase complex subunit; CycH; cyclin H; cyclin-dependent kinase-activating kinase complex subunit; cyclin-H; MO15-associated protein; OTTHUMP00000222395; OTTHUMP00000222396; p34; p37
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 66671, 902
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P51946, Q61458
• Gene Symbols: CCNH
• Immunogen: A synthesized peptide derived from human CCNH(Accession P51946), corresponding to amino acid residues T291-L323.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG