Invitrogen™ Cyclin C Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA593046

Product Code. 16508361

Description

Immunogen sequence: MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS; Positive Samples: MCF7, NIH/3T3, Mouse liver, Mouse kidney, Rat liver; Cellular Location: Nucleus.

Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk 8, a novel protein kinase of the cdk family. It is suggested that cyclin C and cdk 8 control RNA polymerase II function. Human cdk 8 cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth regulatory signals.

Specifications

• Antigen: Cyclin C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNC
• Gene Alias: AI451004; AU020987; CCNC; CG1C; CycC; cyclin C; cyclin-C; dJ199J3.4 (cyclin C); hSRB11; SRB11 homolog
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114839, 51813, 892
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P24863, P39947, Q62447
• Gene Symbols: CCNC
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human Cyclin C (NP_0051812).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG