Invitrogen™ Cyclin B3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA537254

Product Code. 15514321

Description

This antibody detects endogenous protein at a molecular weight of 158 kDa. Purity is >95% by SDS-PAGE.

Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity. Cyclin B3, also known as CCNB3 or CYCB3, is a 1,395 amino acid nuclear protein that belongs to the cyclin family of regulatory proteins. Expressed in testis with lower expression in a variety of other tissues, cyclin B3 is thought to be required for early meiotic prophase I, playing an important role in the meiotic cell cycle. Three isoforms of cyclin B3 exist due to alternative splicing events.

Specifications

• Antigen: Cyclin B3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNB3
• Gene Alias: CCNB3; CYCB3; cyclin B3; CyclinB3; G2/mitotic-specific cyclin-B3; Protein Ccnb3; RGD1564367
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 209091, 317389, 85417
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q810T2, Q8WWL7
• Gene Symbols: CCNB3
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin B3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG