Cyclin B2 Mouse anti-Human, CoraLite 488, Clone: 2G8B7, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech CL488-67726-100UL

Product Code. 17264756

Description

Cyclin B2 (CCNB2) is a member of cyclin family proteins, which regulate the activities of cyclin dependent kinases (CDKs) and different cyclins function spatially and temporally in specific phases of the cell cycle. Cyclin B2 serves a key role in progression of G2/M transition. Cyclin B2 has been found to be up-regulated in a variety of human cancers, such as adrenocortical carcinoma, breast carcinoma, colorectal adenocarcinoma, pituitary adenoma and gastric cancer. The aberrant expression of Cyclin B2 deregulates spindle checkpoints in the cell cycle and results in chromosomal instability (CIN), one of the signature phenotypes of most cancers. Moreover, serum circulating Cyclin B2 mRNA expression has been found increased in cancer patients and associated with cancer stage and metastasis status.

Specifications

• Antigen: Cyclin B2
• Classification: Monoclonal
• Concentration: 1000 μg/mL
• Host Species: Mouse
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG2a

• Applications: Immunofluorescence
• Clone: 2G8B7
• Conjugate: CoraLite 488
• Quantity: 100 μL
• Gene ID (Entrez): 9133
• Form: Liquid