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CX-5461, MedChemExpress

Product Code. 16488337
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Product Code. 16488337 Supplier Medchem Express Supplier No. HY13323
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Estimated Shipment: 16-10-2026
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Description

MedChemExpress CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively.

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively.

Specifications

Chemical Name or Material CX-5461
CAS 1138549-36-6
Color Off-White
Purity Grade Notes Research
Molecular Formula C27H27N7O2S
Quantity 5 mg
Solubility Information DMSO : 2 mg/mL (3.89 mM; Need ultrasonic)
SMILES CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1
Molecular Weight (g/mol) 513.61
Formula Weight 513.61
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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