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Invitrogen™ CUEDC2 Polyclonal Antibody

Product Code. 12838492
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Quantity:
100 μg
Unit Size:
100µg
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12838492 100 μg 100µg
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Product Code. 12838492 Supplier Invitrogen™ Supplier No. PA520620

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. PA5-20620 can be used with blocking peptide PEP-0740.

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CUEDC2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CUEDC2
Gene Accession No. A1L131, Q9CXX9, Q9H467
Gene Alias 3010002G01Rik; bA18I14.5; C10orf66; CUE domain containing 2; CUE domain-containing protein 2; CUEDC2; HOYS6; Unknown (protein for MGC:128745)
Gene Symbols CUEDC2
Host Species Rabbit
Immunogen A 19 amino acid peptide from near the carboxy terminus of human CUEDC2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 294009, 67116, 79004
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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