CTNNA3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16892424	Proteintech 13974-1-AP-20UL	20 μL
16882424	Proteintech 13974-1-AP-150UL	150 μL

Descrizione

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alphaTcatenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other alpha-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not show any cross reaction with alphaE-catenin or alphaNcatenin in western blot analysis.

Specifica

• Antigen: CTNNA3
• Applications: Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat, Human
• Gene Accession No.: Q65CL1, Q9UI47
• Gene ID (Entrez): 216033, 29119, 361839
• Immunogen: CTNNA3 Fusion Protein Ag5008
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CTNNA3

• Concentration: 0.29 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Alpha T catenin, Cadherin associated protein, Catenin alpha 3, CTNNA3, VR22
• Gene Symbols: Ctnna3
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody