Invitrogen™ CTHRC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA538054

Product Code. 15564981

Description

A recommended positive control is rat small intestine tissue lysate. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.

Specifications

• Antigen: CTHRC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cthrc1
• Gene Alias: 1110014B07Rik; collagen triple helix repeat containing 1; collagen triple helix repeat-containing protein 1; CTHRC1; Protein NMTC1; UNQ762/PRO1550
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 115908, 282836, 68588
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8CG08, Q96CG8, Q9D1D6
• Gene Symbols: Cthrc1
• Immunogen: 19 amino acid peptide near the amino terminus of human CTHRC1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG