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Invitrogen™ CTDSP1 Polyclonal Antibody
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100 μL
Unit Size:
100µL
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16613075 100 μL 100µL
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Product Code. 16613075 Supplier Invitrogen™ Supplier No. PA5106634

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CTDSP1.

CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTDSP1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CTDSP1
Gene Accession No. P58466, Q9GZU7
Gene Alias carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; CTD small phosphatase 1; Ctdsp1; GIP; golli-interacting protein; Nif3; Nliif; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; small CTD phosphatase 1; Small C-terminal domain phosphatase 1
Gene Symbols CTDSP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CTDSP1(Accession Q9GZU7), corresponding to amino acid residues M1-L39.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 227292, 363249, 58190
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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