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Invitrogen™ CTCF Monoclonal Antibody (1D11)

Product Code. 12867812
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
12867812 100 μL 100µL
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Product Code. 12867812 Supplier Invitrogen™ Supplier No. MA515792

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Description

Mouse Monoclonal Antibody

MA5-15792 targets CTCF in indirect ELISA, WB applications and shows reactivity with Human and Non-human primate samples. The MA5-15792 immunogen is purified recombinant fragment of human CTCF expressed in E. Coli. MA5-15792 detects CTCF which has a predicted molecular weight of approximately 83kDa.

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTCF
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1D11
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene CTCF
Gene Accession No. P49711, Q61164
Gene Alias 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
Gene Symbols CTCF
Host Species Mouse
Immunogen Purified recombinant fragment of human CTCF expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10664, 13018
Target Species Human, Mouse, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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