CSK Recombinant Rabbit Monoclonal Antibody (5H3L21), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen 703673

Product Code. 16555631

Description

This antibody is predicted to react with Monkey, Mouse, Pig. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

Specifications

• Antigen: CSK
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide, pH 7.4
• Gene Accession No.: P41240
• Gene Symbols: CSK
• Immunogen: Protein corresponding to human CSK [aa73-aa178]
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Clone: 5H3L21
• Conjugate: Unconjugated
• Gene: CSK
• Gene Alias: AW212630, CSK, CSK, non-receptor tyrosine kinase, C-SRC kinase, c-src tyrosine kinase, C-terminal Src kinase, MGC117393, p50CSK, protein-tyrosine kinase (CSK), protein-tyrosine kinase CYL, Protein-tyrosine kinase MPK-2, Tyrosine-protein kinase CSK
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1445
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid