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Invitrogen™ CSK Polyclonal Antibody
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Product Code. 17471553 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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17471553 100 μL 100µL
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Product Code. 17471553 Supplier Invitrogen™ Supplier No. PA5117893

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Description

Rabbit Polyclonal Antibody

CSK Polyclonal Antibody for Western Blot, IHC (P), IP

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
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Specifications

Antigen CSK
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.03% ProClin 300; pH 7
Gene CSK
Gene Accession No. P41240
Gene Alias AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Symbols CSK
Host Species Rabbit
Immunogen E. coli-derived Human CSK fragment.
Purification Method Antigen affinity chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1445
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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