Invitrogen™ CRYGS Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA569836

Product Code. 15868243

Description

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 82%.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Specifications

• Antigen: CRYGS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRYGS
• Gene Alias: AI327013; Beta-crystallin S; beta-crystallin S-like protein; CRYG8; CRYGS; crystallin gamma S; crystallin, gamma 8; crystallin, gamma polypeptide 8; crystallin, gamma S; CTRCT20; Gamma-crystallin S; gamma-crystallin S; beta-crystallin S; gamma-S-crystallin; gammaS-crystallin; opacity due to poor secondary fiber cell junction; Opj; recessive nuclear cataract; rncat; unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 689897
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P0C5E9
• Gene Symbols: CRYGS
• Immunogen: synthetic peptide directed towards the middle region of human CRYGS (aa 121-170).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG