Invitrogen™ CRYGC Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527830

Product Code. 13411977

Description

Recommended positive controls: A431, mouse eye. Predicted reactivity: Mouse (83%), Rat (85%), Dog (87%), Rhesus Monkey (96%), Chimpanzee (99%), Bovine (85%), Guinea pig (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Specifications

• Antigen: CRYGC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRYGC
• Gene Alias: CCL; Cryg; Cryg3; Cryg-5; Crygc; crystallin gamma C; crystallin, gamma C; crystallin, gamma polypeptide 3; CTRCT2; Gammab-cry; Gamma-C-crystallin; gammaC-crystallin; gamma-crystallin 2-1; Gamma-crystallin 3; gamma-crystallin C; Gamma-crystallin IIIA; Len
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12966, 1420
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P07315, Q61597
• Gene Symbols: CRYGC
• Immunogen: Recombinant protein encompassing a sequence within the center region of human gamma C Crystallin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG