Invitrogen™ CRISP2 Monoclonal Antibody (350814)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA561179

Product Code. 30536213

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

The cysteine-rich secretory proteins (CRISP) family is a group of four proteins that are strongly expressed in the male reproductive tract and have been implicated in having roles in male fertility. CRISP2, also known as TPX1, has been implicated in the adhesion between spermatids and Sertoli cells, and with CRISP1, is thought to be involved in sperm-egg fusion. CRISP2 has been shown to regulate the Ca2+ influx through ryanodine receptors (RYR) and may influence the acrosome reaction or sperm motility. CRISP2 has also been shown to bind to the mitogen-activated protein kinase kinase kinase 11 (MAP3K11) and localizes to the developing acrosome, suggesting this CRISP2-MAP3K11 complex may have a role in acrosome development.

Specifications

• Antigen: CRISP2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with trehalose and no preservative
• Gene Accession No.: P16562
• Gene Symbols: CRISP2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CRISP-2, Lys22-Tyr243.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 350814
• Conjugate: Unconjugated
• Gene: CRISP2
• Gene Alias: Cancer/testis antigen 36; CRISP2; CRISP-2; Crisp2l; CT36; cysteine rich secretory protein 2; cysteine-rich secretory protein 2; cysteine-rich secretory protein 2-like; GAPDL5; glyceraldehyde-3-phosphate dehydrogenase-like 5; MGC111136; OTTHUMP00000016589; testicular tissue protein Li 43; testis specific gene 1; testis specific protein 1; testis specific protein 1 (probe H4-1 p3-1); testis-specific protein TPX-1; TPX1; Tpx-1; TSP1
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 7180
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized