CRBN Recombinant Rabbit Monoclonal Antibody (PSH0-69), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen MA549359

Product Code. 17971421

Description

Sequence Similarities: 95% Mouse/Rat. Tissue Specificity: Widely expressed. Highly expressed in brain. Positive Control: HEK-293 cell lysate, A375 cell lysate, A549 cell lysate, HeLa cell lysate, SH-SY5Y cell lysate, NIH/3T3 cell lysate, MCF7 cell lysate, mouse brain tissue lysate, rat testis tissue lysate, human testis tissue, human brain tissue. Subcellular Location: Cytoplasm, Nucleus, Membrane. Predicted band size: 51 kDa.

CRBN, a member of the Lon protease protein family, plays a role in brain development. It is a component of the DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. CRBN is thought to regulate the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. It is widely expressed and highly expressed in brain.

Specifications

• Antigen: CRBN
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q56AP7, Q8C7D2, Q96SW2
• Gene Symbols: CRBN
• Immunogen: Recombinant protein within human crbn aa 1-442 / 442.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: PSH0-69
• Conjugate: Unconjugated
• Gene: CRBN
• Gene Alias: 2610203G15Rik; 2900045O07Rik; AD-006; AF229032; AW108261; cereblon; CRBN; DKFZp781K0715; MGC27358; MRT2; MRT2A; novel lethal; piL; protein cereblon; Protein PiL; protein x 0001
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 297498, 51185, 58799
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Isotype: IgG